24 h area
under the curve (unbound concentration) greater than 100 mg/L*h/MIC (Santimaleeworagun,
Changpradub et al. 2021)
“the MIC median (MIC50), MIC for 90% growth (MIC90), and
range for linezolid were 1.5 µg/mL, 2 µg/mL, and 0.72 - 2 µg/mL, respectively” (Santimaleeworagun,
Changpradub et al. 2021)
The
NextDose default MIC for linezolid is 2 mg/L. The MIC can be changed by adding
MIC observations to patient data.
The
occasion by occasion table of parameters and other variables shows the Bayesian
estimate of clearance (CL L/h), the % difference of the Bayesian clearance from
the group clearance value (fCL%), the Bayesian
estimate of volume of distribution (V L), the % difference of the Bayesian
volume from the group volume value (fV%), the
Bayesian estimate of bioavailability (F), the % difference of the Bayesian
bioavailability from the group bioavailability value (fF%),
the predicted fat free mass (FFM kg), the predicted renal function (RF%), the
minimum inhibitory concentration used for the target (MIC) and the Bayesian
estimate of the baseline platelet count (PLT0).
Santimaleeworagun, W., D. Changpradub, J. Hemapanpairoa and S.
Thunyaharn (2021). "Optimization of linezolid dosing regimens for
treatment of vancomycin-resistant enterococci infection." Infection &
chemotherapy 53(3): 503.
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Holford 2012-2024