Last updated 1 November 2023
Changes: Describes updates to NextDose starting
with the most recent changes
Background: An introduction to Bayesian forecasting
concepts and the development of NextDose
Getting Started:
A quick start guide
showing how to use NextDose.
Target
Concentration: The
target concentration principle for rational dose individualization. How to
decide on a target. When to observe the drug concentration (or other response).
Target Concentration Intervention:
The first dose and
next steps of target concentration intervention. How doses are calculated and
how to choose a practical dose for administration.
Target Types: A list of types of target
available in NextDose
Observation Types: A list of types of observations available
in NextDose
Dose Prediction:
The method used for
prediction of the dose to achieve the user specified target depends on the
target. The choices of methods available to the user are described.
Individual
Parameters: NextDose
uses patient factors (covariates) and observed concentrations (or other
responses) to estimate individual pharmacokinetic (and pharmacodynamic)
parameters. A description of some key covariate models and interpretation of
individual parameters and covariate effects are provided for some of the main
medicines available in NextDose
Options: There are a range of options available to
reflect patient details and ways of using NextDose including ‘what if’ choices.
Medicines
Summary: An
overview of the medicines supported by NextDose
Medicines:
A description of the
individual medicines.
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